Ontogeny of Intestinal Epithelial Innate Immune Responses
نویسندگان
چکیده
Emerging evidence indicates that processes during postnatal development might significantly influence the establishment of mucosal host-microbial homeostasis. Developmental and adaptive immunological processes but also environmental and microbial exposure early after birth might thus affect disease susceptibility and health during adult life. The present review aims at summarizing the current understanding of the intestinal epithelial innate immune system and its developmental and adaptive changes after birth.
منابع مشابه
Current Concepts in Mucosal Immunity III. Ontogeny and function of gd T cells in the intestine*
Kagnoff, Martin F. Current Concepts in Mucosal Immunity. III. Ontogeny and function of gd T cells in the intestine. Am. J. Physiol. 274 (Gastrointest. Liver Physiol. 37): G455– G458, 1998.—gd T cells are located in the paracellular space between epithelial cells. In the human colon and small intestine, 5–40% of intraepithelial lymphocytes (IEL) are gd T cells, and in mice an even greater propor...
متن کاملSalmonella Typhimurium Type III Secretion Effectors Stimulate Innate Immune Responses in Cultured Epithelial Cells
Recognition of conserved bacterial products by innate immune receptors leads to inflammatory responses that control pathogen spread but that can also result in pathology. Intestinal epithelial cells are exposed to bacterial products and therefore must prevent signaling through innate immune receptors to avoid pathology. However, enteric pathogens are able to stimulate intestinal inflammation. W...
متن کاملInhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells.
Enterohepatic Helicobacter species infect the intestinal tracts and biliary trees of various mammals, including mice and humans, and are associated with chronic inflammatory diseases of the intestine, gallstone formation, and malignant transformation. The recent analysis of the whole genome sequence of the mouse enterohepatic species Helicobacter hepaticus allowed us to perform a functional ana...
متن کاملTHE INNATE AND ADAPTIVE IMMUNE SYSTEM OF THE INTESTINAL EPITHELIUM PER BRANDTZAEG Laboratory for Immunohistochemistry and Immunopathology (LIIPAT),
It is increasingly being appreciated that innate immune mechanisms play a key role for the tuning of adaptive immunity in the gut and maintenance of mucosal homeostasis. Innate responses use preformed and rapidly synthesised effectors and sensors that lead to spontaneous activation or modulation of cellular functions, aiming at elimination of microbial challenges and return of the local tissue ...
متن کاملProbiotics promote gut health through stimulation of epithelial innate immunity.
Probiotic formulations are widely available and have a variety of proposed beneficial effects, including promotion of gut health. The mechanisms of action of probiotic bacteria in the intestine are still unclear but are generally attributed to an antiinflammatory effect. Here, we demonstrate that the multiple probiotic formulation VSL#3 prevents the onset of intestinal inflammation by local sti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2014